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Immunol Res. 2006;36(1-3):221-8.

Age-dependent alterations of the T cell repertoire and functional diversity of T cells of the aged.

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1
Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. abbe.vallejo@chp.edu

Abstract

The aging immune system is characterized by the contraction of T cell receptor (TCR) diversity and the de novo expression of NKrelated receptors (NKR) on oligoclonal T cells. NKR+ T cells likely represent a secondary immune diversification as a biological adaptation of aging to ensure host defense despite shrinkage of the TCR repertoire. NKRs are expressed in various combinations even among TCR-identical cells, and are capable of triggering effector pathways in either TCR-independent or TCR-dependent fashion. Understanding the biology of NKR+ T cells will be pivotal to the development of strategies to enhance immunity in the elderly.

PMID:
17337782
DOI:
10.1385/IR:36:1:221
[Indexed for MEDLINE]
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