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FEBS Lett. 2007 May 22;581(11):2112-8. Epub 2007 Feb 20.

Regulating cytoskeleton-based vesicle motility.

Author information

1
Department of Molecular Physiology and Biophysics, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA

Abstract

During vesicular transport, the assembly of the coat complexes and the selection of cargo proteins must be coordinated with the subsequent translocation of vesicles from the donor to an acceptor compartment. Here, we review recent progress toward uncovering the molecular mechanisms that connect transport vesicles to the protein machinery responsible for cytoskeleton-mediated motility. An emerging theme is that vesicle cargo proteins, either directly or through binding interactions with coat proteins, are able to influence cytoskeletal dynamics and motor protein function. Hence, a vesicle's cargo composition may help direct its intracellular motility and targeting.

PMID:
17335816
PMCID:
PMC1974873
DOI:
10.1016/j.febslet.2007.01.094
[Indexed for MEDLINE]
Free PMC Article

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