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Br J Clin Pharmacol. 2007 Aug;64(2):237-40. Epub 2007 Mar 1.

Dihydropyrimidine dehydrogenase activity and the IVS14+1G>A mutation in patients developing 5FU-related toxicity.

Author information

1
Institut Gustave Roussy, Villejuif, France.

Abstract

AIMS:

To examine retrospectively the relationship between DPD phenotype/genotype and the intensity of 5FU toxicity.

METHODS:

One hundred and thirty-one case-reports (81 women, 50 men) with 5FU-related toxicity were analyzed.

RESULTS:

The lower the DPD activity (10-504 pmol min(-1) mg(-1)), the higher the toxicity grade was scored (P < 0.01). Toxicity-related deaths occurred in nine patients (eight women) who significantly expressed lower DPD activity than other patients. Two of the deceased patients had normal DPD activity. The IVS14+1G>A mutation, analyzed in 93 patients, was detected in two patients (nonlethal toxicity).

CONCLUSIONS:

The IVS14+1G>A mutation may not help prevent toxicity and patients with normal DPD activity may develop life-threatening 5FU toxicity.

PMID:
17335544
PMCID:
PMC2000632
DOI:
10.1111/j.1365-2125.2007.02869.x
[Indexed for MEDLINE]
Free PMC Article

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