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Bioconjug Chem. 2007 Mar-Apr;18(2):579-84. Epub 2007 Mar 3.

Synthesis of symmetrical and unsymmetrical PAMAM dendrimers by fusion between azide- and alkyne-functionalized PAMAM dendrons.

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1
Department of Chemistry, Dong-A University, Hadan-2-dong, Busan 604-714, Korea. jlee@donga.ac.kr

Abstract

A new convergent synthetic method for the synthesis of PAMAM dendrimers has been developed. The fusion between propargyl-functionalized PAMAM dendrons and azido-functionalized PAMAM dendrons via the Cu(I)-catalyzed Huisgen [2 + 3] dipolar cycloaddition reaction (click chemistry) of an alkyne and an azide leads to the formation of symmetric PAMAM dendrimers in high yields. Furthermore, the coupling reactions between the different generation dendrons afford the size-differentiated unsymmetrical PAMAM dendrimers.

PMID:
17335177
DOI:
10.1021/bc060256f
[Indexed for MEDLINE]
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