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South Med J. 2007 Feb;100(2):212-4.

Oxycodone accumulation in a hemodialysis patient.

Author information

1
Alegent Health, Bergan Mercy Medical Center, and Creighton University, Omaha, NE, USA. pforal@creighton.edu

Abstract

Oxycodone and oxycodone-containing analgesics are often used for the relief of pain. In the presence of renal dysfunction, the half-life of oxycodone and metabolites can be prolonged. We describe the case of a 41-year-old chronic hemodialysis patient who received multiple doses of oxycodone/acetaminophen resulting in accumulation of the medication and consequent lethargy, hypotension and respiratory depression. These adverse effects were reversed with multiple bolus doses of naloxone, followed by a continuous infusion administered for 45 hours. Utilizing the Naranjo probability scale, the patient had a "probable" adverse drug reaction to the oxycodone. Oxycodone should be used with caution in patients with chronic renal failure.

[Indexed for MEDLINE]

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