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EMBO Rep. 2007 Mar;8(3):241-6.

Phosphoinositide-metabolizing enzymes at the interface between membrane traffic and cell signalling.

Author information

1
Department of Membrane Biochemistry, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustrasse 6, 14195 Berlin, Germany.

Abstract

Phosphoinositides (PIs) have long been known to have important roles in cell signalling. During the past decade, it has become clear that these lipids also act as constitutive signals that aid in defining organelle identity, and are short-lived recruiters and regulators of cytoskeletal and membrane dynamics. Recent studies have provided important clues as to how regulated activation of PI-metabolizing enzymes and recruitment of their binding proteins might cooperate in targeting distinct pools of PIs to different cell physiological functions.

PMID:
17330069
PMCID:
PMC1808040
DOI:
10.1038/sj.embor.7400919
[Indexed for MEDLINE]
Free PMC Article

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