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Chem Pharm Bull (Tokyo). 2007 Mar;55(3):376-81.

Two minor diterpene glycosides and an eudesman sesquiterpene from Coleus forskohlii.

Author information

1
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, The People's Republic of China.

Abstract

Two new labdane diterpene glycosides, forskoditerpenosides A, B (1, 2) and a new eudesmane sesquiterpene, 4beta,7beta,11-enantioeudesmantriol (3), were isolated from the ethanol extract of the whole plant of Coleus forskohlii. Their structures and stereochemistry were elucidated by extensive spectroscopic analysis and chemical methods. The structure of compound 3 was confirmed by X-ray diffraction. This is the first report about the occurrence of glycosides derived from the kind of labdane diterpene, 8,13-epoxy-labd-14-en-11-one, in the nature. Compounds 1 and 2 showed relaxative effects on isolated guinea pig tracheal spirals in vitro.

PMID:
17329875
DOI:
10.1248/cpb.55.376
[Indexed for MEDLINE]
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