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Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Mar 1;63(Pt 3):150-3. Epub 2007 Feb 13.

A high-resolution structure of ligand-free human glutamate carboxypeptidase II.

Author information

1
National Cancer Institute at Frederick, Center for Cancer Research, Frederick, MD 21702, USA. cyril@ncifcrf.gov

Abstract

Human glutamate carboxypeptidase II (GCPII; EC 3.4.17.21) is an established marker for prostate-cancer diagnosis as well as a candidate therapeutic target for the treatment of diverse pathologies that involve glutamatergic transmission. Structural data on GCPII are thus valuable for the design and optimization of GCPII-specific inhibitors and diagnostic probes. The currently available structure of ligand-free GCPII was refined to a resolution of 3.5 A. This work reports the structure of the protein refined to 1.65 A resolution, with crystallographic values of R = 0.207 and R(free) = 0.228. The new structure extends the resolution appreciably and the new model based on this data shows significant differences when compared with the previously published model.

PMID:
17329803
PMCID:
PMC2330195
DOI:
10.1107/S174430910700379X
[Indexed for MEDLINE]
Free PMC Article

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