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J Virol. 2007 May;81(9):4904-8. Epub 2007 Feb 28.

Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypes.

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1
Partners AIDS Research Center, Massachusetts General Hospital East, 149 13th Street, Charlestown, MA 02129-2000, USA.

Abstract

The cellular immunity against Kaposi's sarcoma-associated herpesvirus (KSHV) is poorly characterized and has not been compared to T-cell responses against other human herpesviruses. Here, novel and dominant targets of KSHV-specific cellular immunity are identified and compared to T cells specific for lytic and latent antigens in a second human gammaherpesvirus, Epstein-Barr virus. The data identify a novel HLA-B57- and HLA-B58-restricted epitope in the Orf57 protein and show consistently close parallels in immune phenotypes and functional response patterns between cells targeting lytic or latent KSHV- and EBV-encoded antigens, suggesting common mechanisms in the induction of these responses.

PMID:
17329344
PMCID:
PMC1900166
DOI:
10.1128/JVI.02509-06
[Indexed for MEDLINE]
Free PMC Article
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