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Neuron. 2007 Mar 1;53(5):747-59.

Developmental downregulation of histone posttranslational modifications regulates visual cortical plasticity.

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1
Scuola Normale Superiore, Neurobiology Laboratory, Area Ricerca CNR, via Moruzzi, 1 Pisa 56125, Italy.

Erratum in

  • Neuron. 2007 Apr 5;54(1):177.

Abstract

The action of visual experience on visual cortical circuits is maximal during a critical period of postnatal development. The long-term effects of this experience are likely mediated by signaling cascades regulating experience-dependent gene transcription. Developmental modifications of these pathways could explain the difference in plasticity between the young and adult cortex. We studied the pathways linking experience-dependent activation of ERK to CREB-mediated gene expression in vivo. In juvenile mice, visual stimulation that activates CREB-mediated gene transcription also induced ERK-dependent MSK and histone H3 phosphorylation and H3-H4 acetylation, an epigenetic mechanism of gene transcription activation. In adult animals, ERK and MSK were still inducible; however, visual stimulation induced weak CREB-mediated gene expression and H3-H4 posttranslational modifications. Stimulation of histone acetylation in adult animals by means of trichostatin promoted ocular dominance plasticity. Thus, differing, experience-dependent activations of signaling molecules might be at the basis of the differences in experience-dependent plasticity between juvenile and adult cortex.

PMID:
17329213
DOI:
10.1016/j.neuron.2007.02.007
[Indexed for MEDLINE]
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