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J Ethnopharmacol. 2007 May 30;112(1):7-12. Epub 2007 Jan 30.

Antiparasitic activity of some New Caledonian medicinal plants.

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Laboratoire de Pharmacognosie (UMR CNRS 8076-BioCIS), Université Paris-Sud 11, Faculté de Pharmacie, 92296 Châtenay-Malabry, France.


Twenty-nine extracts of 18 medicinal plants used in New Caledonia by traditional healers to treat inflammation, fever and in cicatrizing remedies were evaluated in vitro against several parasites (Leishmania donovani, Trypanosoma brucei brucei, Trichomonas vaginalis and Caenorhabditis elegans). Among the selected plants, Scaevola balansae and Premna serratifolia L. were the most active against Leishmania donovani with IC(50) values between 5 and 10microg/ml. The almond and aril extracts from Myristica fatua had an IC(50) value of 0.5-5microg/ml against Trypanosoma brucei brucei. Only Scaevola balansae extract presented a weak activity against Trichomonas vaginalis. The almond extract from Myristica fatua presented significant activity against Caenorhabditis elegans (IC(50) value of 6.6+/-1.2microg/ml).

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