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Org Lett. 2007 Mar 29;9(7):1243-6. Epub 2007 Mar 1.

Enantioselective hydrogenation of quinolines catalyzed by Ir(BINAP)-cored dendrimers: dramatic enhancement of catalytic activity.

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1
Beijing National Laboratory for Molecular Sciences, Center for Chemical Biology, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China.

Abstract

[structure: see text]. The asymmetric hydrogenation of quinolines catalyzed by chiral dendritic catalysts derived from BINAP gave the corresponding products with high enantioselectivities (up to 93%), excellent catalytic activities (TOF up to 3450 h(-1)), and productivities (TON up to 43,000). In addition, the third-generation catalyst could be recovered by precipitation and filtration and reused at least six times with similar enantioselectivity.

PMID:
17328554
DOI:
10.1021/ol0631410
[Indexed for MEDLINE]
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