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Curr Opin Investig Drugs. 2007 Feb;8(2):159-67.

Drug evaluation: DNA/MVA prime-boost HIV vaccine.

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  • 1University of Melbourne, Department of Microbiology and Immunology, Melbourne, Victoria 3010, Australia.


Oxford University and Nairobi University are jointly developing a HIVA.DNA/modified vaccinia Ankara (MVA) prime-boost vaccine for the potential prevention of infection with HIV subtype A. The vaccination strategy consists of priming with a DNA vaccine made from HIV-1 clade A gag p24/p17 consensus sequence (pTHr.HIVA) then boosting with a MVA virus expressing HIVA (MVA.HIVA). Phase II clinical trials of the vaccine are underway in Kenya and the UK.

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