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J Intellect Disabil Res. 2007 Apr;51(Pt 4):312-7.

Natural history of thyroid function in adults with Down syndrome--10-year follow-up study.

Author information

1
Greenfields, Kings Norton, Birmingham, UK. vprasher@compuserve.com

Abstract

BACKGROUND:

The natural history of thyroid function in adults with Down syndrome (DS) is unknown.

METHOD:

This study investigated annual thyroid function tests in 200 adults with DS over a 10-year period.

RESULTS:

Transient and persistent thyroid dysfunction was common. The 5- and 10-year incidence of definite hypothyroidism was 0.9%-1.64% and 13.6%, respectively. Subclinical hypothyroidism was not found to be an early sign for definite hypothyroidism.

CONCLUSIONS:

Routine screening for adults with DS who are euthyroid can be reduced to every 5 years rather than the present policy of every 1-2 years.

[Indexed for MEDLINE]

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