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J Antimicrob Chemother. 2007 Mar;59(3):553-5.

In vitro susceptibility of Madurella mycetomatis, prime agent of Madura foot, to tea tree oil and artemisinin.

Author information

1
Department of Medical Microbiology & Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands. w.vandesande@erasmusmc.nl

Abstract

OBJECTIVES:

Eumycetoma caused by Madurella mycetomatis is treated with surgery and high doses of itraconazole and ketoconazole. These agents are toxic, and new therapies are required.

METHODS:

MICs were determined for artemisinin and tea tree oil, two natural herbal compounds.

RESULTS:

Artemisinin was not active against M. mycetomatis, but tea tree oil did inhibit its growth. Since tea tree oil's prime component easily penetrates the skin, tea tree oil could be a useful agent in the treatment of eumycetoma.

CONCLUSIONS:

Tea tree oil is active in vitro against M. mycetomatis.

PMID:
17324961
DOI:
10.1093/jac/dkl526
[Indexed for MEDLINE]

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