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Eur J Echocardiogr. 2007 Oct;8(5):360-8. Epub 2007 Feb 23.

Maternal left ventricular diastolic and systolic long-axis function during normal pregnancy.

Author information

1
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, Denmark Hill, Golden Jubilee Wing, London SE5 9RS, UK. jbamfo1@hotmail.com

Abstract

AIMS:

The aim of this study was to evaluate left ventricular (LV) function during normal pregnancy and investigate the effect of maternal factors. Little information about LV diastolic and long-axis systolic function in normal pregnancy exists.

METHODS AND RESULTS:

Two hundred and twenty eight Doppler echocardiography and DTI studies of the mitral annulus were performed in 63 normal pregnant women longitudinally at 11-14, 20-24, 26-32, 33-38weeks and 8-12weeks postpartum. Cardiac output, stroke volume and heart rate increased during pregnancy and total vascular resistance decreased. Long-axis shortening decreased, transmitral A velocity increased (p=0.003) and the ratio of transmitral E to A velocity decreased (p=0.001). DTI early diastolic velocity (E') decreased and late diastolic velocity (A') remained unaltered. DTI systolic velocity (S') and the E/E' ratio did not change significantly during pregnancy. Tei index increased throughout pregnancy (p=0.03). Maternal age was related to E velocity (p=0.001) and E/A ratio (p=0.001) while ethnicity was related to cardiac output (p<0.001), stroke volume (p<0.02) and heart rate (p<0.0001).

CONCLUSION:

This study gives normal ranges for Doppler tissue imaging measurements, but demonstrates that maternal characteristics may affect these and all measures of systolic and diastolic function.

PMID:
17321800
DOI:
10.1016/j.euje.2006.12.004
[Indexed for MEDLINE]
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