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Cell. 2007 Feb 23;128(4):787-800.

Beyond the sequence: cellular organization of genome function.

Author information

1
National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. mistelit@mail.nih.gov

Abstract

Genomes are more than linear sequences. In vivo they exist as elaborate physical structures, and their functional properties are strongly determined by their cellular organization. I discuss here the functional relevance of spatial and temporal genome organization at three hierarchical levels: the organization of nuclear processes, the higher-order organization of the chromatin fiber, and the spatial arrangement of genomes within the cell nucleus. Recent insights into the cell biology of genomes have overturned long-held dogmas and have led to new models for many essential cellular processes, including gene expression and genome stability.

PMID:
17320514
DOI:
10.1016/j.cell.2007.01.028
[Indexed for MEDLINE]
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