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PLoS Genet. 2007 Feb 23;3(2):e32.

Elevated rates of sister chromatid exchange at chromosome ends.

Author information

1
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

Abstract

Chromosome ends are known hotspots of meiotic recombination and double-strand breaks. We monitored mitotic sister chromatid exchange (SCE) in telomeres and subtelomeres and found that 17% of all SCE occurs in the terminal 0.1% of the chromosome. Telomeres and subtelomeres are significantly enriched for SCEs, exhibiting rates of SCE per basepair that are at least 1,600 and 160 times greater, respectively, than elsewhere in the genome.

PMID:
17319749
PMCID:
PMC1802831
DOI:
10.1371/journal.pgen.0030032
[Indexed for MEDLINE]
Free PMC Article

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