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J Mammary Gland Biol Neoplasia. 2007 Mar;12(1):71-82.

Microenvironment of the involuting mammary gland mediates mammary cancer progression.

Author information

1
AMC Cancer Research Center, University of Colorado Health Science Center, Aurora, CO, USA. Pepper.schedin@uchsc.edu

Abstract

Breast cancer diagnosed after a completed pregnancy has higher metastatic potential and therefore a much poorer prognosis. We hypothesize that following pregnancy the process of mammary gland involution, which returns the gland to its pre-pregnant state, co-opts some of the programs of wound healing. The pro-inflammatory milieu that results, while physiologically normal, promotes tumor progression. In this review, the similarities between mammary gland involution after cessation of milk-production and pathological tissue remodeling are discussed in light of emerging data demonstrating a role for pathological tissue remodeling in cancer.

PMID:
17318269
DOI:
10.1007/s10911-007-9039-3
[Indexed for MEDLINE]

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