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Mol Cell. 2007 Feb 23;25(4):483-5.

Prolyl cis-trans Isomerization as a molecular timer in Crk signaling.

Author information

1
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA. lkn2@cornell.edu

Abstract

In a recent issue of Molecular Cell, use NMR to identify peptidyl-prolyl cis-trans isomerization as an autoinhibitory switch in the adaptor protein Crk, suggesting a new mechanism for controlling the rate of formation of signaling complexes.

PMID:
17317620
DOI:
10.1016/j.molcel.2007.02.005
[Indexed for MEDLINE]
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