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Trends Cell Biol. 2007 Apr;17(4):193-201. Epub 2007 Feb 20.

CRM1-mediated nuclear export: to the pore and beyond.

Author information

1
Universität Göttingen; Zentrum für Biochemie und Molekulare Zellbiologie; Humboldtallee 23; 37073 Göttingen, Germany.

Abstract

CRM1 (chromosome region maintenance 1; also referred to as exportin1 or Xpo1) is a member of the importin beta superfamily of nuclear transport receptors, recognizing proteins bearing a leucine-rich nuclear export sequence. CRM1 is the major receptor for the export of proteins out of the nucleus and is also required for transport of many RNAs. Besides its established role in nuclear export, CRM1 is also implicated in various steps during mitosis, widening its functional spectrum within the cell.

PMID:
17317185
DOI:
10.1016/j.tcb.2007.02.003
[Indexed for MEDLINE]

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