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Mutat Res. 2007 May 1;618(1-2):18-29. Epub 2007 Jan 21.

INO80 subfamily of chromatin remodeling complexes.

Author information

1
Department of Carcinogenesis, Science Park Research Division, University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA.

Abstract

ATP-dependent chromatin remodeling complexes contain ATPases of the Swi/Snf superfamily and alter DNA accessibility of chromatin in an ATP-dependent manner. Recently characterized INO80 and SWR1 complexes belong to a subfamily of these chromatin remodelers and are characterized by a split ATPase domain in the core ATPase subunit and the presence of Rvb proteins. INO80 and SWR1 complexes are evolutionarily conserved from yeast to human and have been implicated in transcription regulation, as well as DNA repair. The individual components, assembly patterns, and molecular mechanisms of the INO80 class of chromatin remodeling complexes are discussed in this review.

PMID:
17316710
PMCID:
PMC2699258
DOI:
10.1016/j.mrfmmm.2006.10.006
[Indexed for MEDLINE]
Free PMC Article

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