Format

Send to

Choose Destination
See comment in PubMed Commons below
Head Neck. 2007 Jul;29(7):655-64.

Prognostic impact of HER-2/neu expression on squamous head and neck carcinomas.

Author information

1
Division of Otorhinolaryngology, Department of Clinical Physiopathology, University of Turin, Turin, Italy.

Abstract

BACKGROUND:

HER-2/neu gene amplification and protein overexpression have been identified in various solid tumors, but its prognostic relevance in head and neck squamous cell carcinoma (HNSCC) is still controversial.

METHODS:

The study investigated the expression of HER-2/neu oncoprotein in HNSCC and sought possible correlations to various clinicopathologic parameters. Expression of HER-2/neu oncoprotein was assessed in archival tumor tissues from 87 untreated HNSCC patients by immunohistochemical technique. Data were correlated with both the clinicopathologic parameters and patient survival.

RESULTS:

A high membranous HER-2/neu protein expression level was found in 39% of patients. Multivariate analysis indicated that HER-2/neu protein expression and pN lymph-node status were independent prognostic factors for disease-free survival.

CONCLUSIONS:

HER2/neu overexpression and its relationship with survival suggest that new therapeutic approaches targeting epidermal growth factor receptor (EGFR) family receptors could provide a new way of treating HNSCC patients with HER2/neu-positive neoplastic lesions.

PMID:
17315173
DOI:
10.1002/hed.20574
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center