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ACS Chem Biol. 2007 Feb 20;2(2):99-103.

The 3D structure of protein phosphatase 2A: new insights into a ubiquitous regulator of cell signaling.

Author information

1
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. marc.mumby@utsouthwestern.edu

Abstract

Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase implicated in cancer. Three new crystal structures of PP2A show how it interacts with inhibitory toxins and with one of its regulatory subunits. The structures also explain how specific site mutations may lead to cancer and suggest a novel role for PP2A methylation in the formation of PP2A holoenzymes.

PMID:
17313179
DOI:
10.1021/cb700021z
[Indexed for MEDLINE]

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