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Org Biomol Chem. 2006 Nov 21;4(22):4149-57.

Large scale synthesis of the Cdc42 inhibitor secramine A and its inhibition of cell spreading.

Author information

1
Department of Chemistry, University of Louisville, Louisville, Kentucky, 40292, USA.

Abstract

We describe a large scale synthesis of secramine A. Consistent with its ability to inhibit activation of the small GTPase Cdc42, we find that secramine A inhibits cell spreading, a process previously shown to be Cdc42-dependent.

PMID:
17312971
[Indexed for MEDLINE]

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