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Anesth Analg. 2007 Mar;104(3):548-51.

A comparison of ondansetron with promethazine for treating postoperative nausea and vomiting in patients who received prophylaxis with ondansetron: a retrospective database analysis.

Author information

1
Department of Anesthesiology, Duke University Medical Center, Durham, NC, 27710, USA. habib001@mc.duke.edu

Erratum in

  • Anesth Analg. 2007 Aug;105(2):364.

Abstract

BACKGROUND:

There are little data on the efficacy of antiemetics for treating postoperative nausea and vomiting (PONV) in patients who received prior PONV prophylaxis.

METHODS:

In this retrospective database analysis, we compared the efficacy of ondansetron with that of promethazine for treating PONV in adults receiving general anesthesia who failed ondansetron prophylaxis.

RESULTS:

Three thousand sixty-two patients received ondansetron and 752 received promethazine after failure of ondansetron prophylaxis. The complete response (no PONV and no further rescue) was 68% after administration of promethazine and 50% after ondansetron administration (P < 0.0001). There was no difference in complete response between 6.25 mg and higher doses of promethazine.

CONCLUSIONS:

Promethazine was significantly more effective than ondansetron for treating PONV after failed ondansetron prophylaxis. Promethazine 6.25 mg was as effective as higher doses.

[Indexed for MEDLINE]

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