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Nat Rev Neurosci. 2007 Mar;8(3):194-205.

Neuronal polarity: from extracellular signals to intracellular mechanisms.

Author information

  • 1Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, 65, Tsurumai, Showa, Nagoya, Aichi 466-8550, Japan.

Abstract

After they are born and differentiate, neurons break their previous symmetry, dramatically change their shape, and establish two structurally and functionally distinct compartments - axons and dendrites - within one cell. How do neurons develop their morphologically and molecularly distinct compartments? Recent studies have implicated several signalling pathways evoked by extracellular signals as having essential roles in a number of aspects of neuronal polarization.

PMID:
17311006
DOI:
10.1038/nrn2056
[PubMed - indexed for MEDLINE]
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