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Nat Struct Mol Biol. 2007 Mar;14(3):243-5. Epub 2007 Feb 18.

Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase.

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1
Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295, USA.

Erratum in

  • Nat Struct Mol Biol. 2007 Apr;14(4):351.

Abstract

Histone methylation is important in regulating chromatin structure and function. In budding yeast, methylation of histone H3 at Lys4 (H3-K4) is associated with active transcription and is enriched at the 5' regions of transcribed genes. Here we identify a novel budding yeast JmjC domain-containing H3-K4 demethylase, Jhd2p, that antagonizes the trimethyl modification state and contributes to regulation of telomeric silencing.

PMID:
17310254
DOI:
10.1038/nsmb1204
[Indexed for MEDLINE]
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