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Curr Cancer Drug Targets. 2007 Feb;7(1):79-89.

Mechanisms used by human papillomaviruses to escape the host immune response.

Author information

1
Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA.

Abstract

The greatest risk factor for the development of cervical and other cancers that have been linked to the human papillomavirus (HPV) family is the persistence of the virus. To persist for the decades required to develop HPV-related cancers, the virus must escape host immunity. HPV is a simple DNA virus that has evolved to escape immune attack by a combination of stealth and interference. This review focuses on the mechanisms by which HPV can evade recognition by the host immune system.

PMID:
17305480
[Indexed for MEDLINE]

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