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Org Lett. 2007 Mar 15;9(6):949-52. Epub 2007 Feb 17.

C-acylations of polymeric phosphoranylidene acetates for C-terminal variation of peptide carboxylic acids.

Author information

1
Leibniz Institute for Molecular Pharmacology (FMP), Robert-Rössle-Strasse 10, 13125 Berlin, Germany.

Abstract

C-Acylations of polymer-supported 2-phosphoranylidene acetates ("linker reagents") with protected amino acids yielded 2-acyl-2-phosphoranylidene acetates as flexible intermediates for the C-terminal variation of carboxylic acids: peptidyl-2,3-diketoesters, peptidyl vinyl ketones, peptidyl-2-ketoaldehydes, and 1,3-diamino-2-hydroxy-propanes were obtained as products. [reaction: see text].

PMID:
17305347
DOI:
10.1021/ol062754+
[Indexed for MEDLINE]

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