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Ann Allergy Asthma Immunol. 2007 Feb;98(2):196-9.

A case of common variable immunodeficiency syndrome associated with Takayasu arteritis.

Author information

1
Allergy/Immunology Division, Albert Einstein College of Medicine, Bronx, New York 10461, USA. ejerschow@yahoo.com

Abstract

BACKGROUND:

Association of common variable immunodeficiency (CVID) with Takayasu arteritis has rarely been reported.

OBJECTIVE:

To describe a case of Takayasu arteritis in a 53-year-old Hispanic woman with CVID undergoing long-term (3-year) intravenous immunoglobulin (IVIG) treatment.

METHODS:

The patient's serum immunoglobulin levels and antibody titers to measles, mumps, and rubella were measured. She also underwent angiography of the large vessels.

RESULTS:

Low to undetectable serum IgA, IgM, and IgG levels and low antibody titers to mumps, measles, and rubella were consistent with the diagnosis of CVID. The angiogram showed narrowing of the proximal left subclavian artery (2-3 mm in diameter).

CONCLUSIONS:

This patient developed Takayasu arteritis while receiving IVIG for CVID. She clinically improved after her IVIG dose was increased. To our knowledge, this is the second reported case of Takayasu arteritis associated with CVID.

PMID:
17304891
DOI:
10.1016/S1081-1206(10)60697-7
[Indexed for MEDLINE]

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