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Nat Rev Microbiol. 2007 Mar;5(3):197-208.

Virus trafficking - learning from single-virus tracking.

Author information

1
Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138, USA.

Abstract

What could be a better way to study virus trafficking than 'miniaturizing oneself' and 'taking a ride with the virus particle' on its journey into the cell? Single-virus tracking in living cells potentially provides us with the means to visualize the virus journey. This approach allows us to follow the fate of individual virus particles and monitor dynamic interactions between viruses and cellular structures, revealing previously unobservable infection steps. The entry, trafficking and egress mechanisms of various animal viruses have been elucidated using this method. The combination of single-virus trafficking with systems approaches and state-of-the-art imaging technologies should prove exciting in the future.

PMID:
17304249
PMCID:
PMC2740720
DOI:
10.1038/nrmicro1615
[Indexed for MEDLINE]
Free PMC Article

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