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Bioorg Med Chem Lett. 2007 Apr 15;17(8):2134-8. Epub 2007 Jan 31.

Synthesis and activity of quinolinyl-methylene-thiazolinones as potent and selective cyclin-dependent kinase 1 inhibitors.

Author information

1
Roche Research Center, Hoffmann-La Roche Inc., Nutley, NJ 07110, USA. shaoqing.chen@roche.com

Abstract

A novel series of quinolinyl-methylene-thiazolinones has been identified as potent and selective cyclin-dependent kinase 1 (CDK1) inhibitors. Their synthesis and structure activity relationships (SAR) are described. Representative compounds from this class reversibly inhibit CDK1 activity in vitro, and block cell cycle progression in human tumor cell lines, suggesting a potential use as antitumor agents.

PMID:
17303421
DOI:
10.1016/j.bmcl.2007.01.081
[Indexed for MEDLINE]

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