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Curr Opin Cell Biol. 2007 Apr;19(2):142-9. Epub 2007 Feb 15.

The JNK signal transduction pathway.

Author information

1
Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

Abstract

The c-Jun NH(2)-terminal kinases (JNKs) are an evolutionarily conserved sub-group of mitogen-activated protein (MAP) kinases. Recent studies have improved our understanding of the physiological function of the JNK pathway. Roles of novel molecules that participate in the JNK pathway have been defined and new insight into the role of JNK in survival signaling, cell death, cancer and diabetes has been achieved.

PMID:
17303404
DOI:
10.1016/j.ceb.2007.02.001
[Indexed for MEDLINE]

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