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Br J Clin Pharmacol. 2007 May;63(5):628-31. Epub 2007 Feb 14.

Palatability of angiotensin II antagonists among nephropathic children.

Author information

1
Ospedale San Giovanni Bellinzona and Ospedale della Beata Vergine, Mendrisio, Switzerland.

Abstract

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:

* Among children, medication palatability is crucial for adherence to therapeutic regimen. * Several studies have measured the palatability of antimicrobial suspensions in paediatric patients by means of a visual analogue scale palatability score.

WHAT THIS STUDY ADDS:

* This is the first analysis comparing the taste and smell acceptability of angiotensin II receptor blockers among paediatric patients with kidney disease. * From the perspective of the child with kidney disease, the taste of pulverized candesartan is significantly superior to that of pulverized irbesartan, losartan, telmisartan or valsartan.

AIM:

Angiotensin II receptor blockers are widely prescribed in kidney disease. Among children, medication palatability is crucial for adherence.

METHODS:

Taste and smell acceptability of five angiotensin II receptor blockers were compared among 21 nephropathic children using a visual analogue scale palatability score.

RESULTS:

The score assigned to pulverized tablets of candesartan cilexetil was significantly higher than that assigned to pulverized tablets of irbesartan, losartan, telmisartan and valsartan.

CONCLUSIONS:

From the perspective of the nephropathic child, the taste of pulverized candesartan cilexetil is superior to that of irbesartan, losartan, telmisartan or valsartan.

PMID:
17302913
PMCID:
PMC2000746
DOI:
10.1111/j.1365-2125.2006.02814.x
[Indexed for MEDLINE]
Free PMC Article
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