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J Perinat Med. 2007;35(2):108-14.

Fortified mineral water improves folate status and decreases plasma homocysteine concentration in pregnant women.

Author information

1
Department of Obstetrics and Gynecology, University of Oulu, Oulu, Finland. jouko.jarvenpaa@ppshp.fi

Abstract

OBJECTIVES:

There is no mandatory folic acid fortification of food in Finland. We investigated the effects of mineral water fortified with folic acid, vitamins B6, B12, D and calcium on serum and erythrocyte folate concentrations, serum vitamin B12 and plasma homocysteine concentrations in pregnancy.

DESIGN:

A randomized, controlled, double-blind, parallel-group intervention study.

METHODS:

Seventy-four pregnant women were recruited from two health care units. The study began at the eleventh week with a two-week run-in period, followed by an eight-week intervention period. The diet was monitored by food records. During the intervention, subjects consumed 1000 mL/day fortified or normal mineral water. The pregnancies were monitored carefully.

RESULTS:

The folate intake was 255 microg/day in the study group and 274 microg/day in the controls. Serum folate concentrations increased in the study group by 10.3 nmol/L and decreased in the controls by 2.7 nmol/L (P<0.05) during the study. The erythrocyte folate concentrations increased in the study group by 360.9 nmol/L and in the controls by 195.6 nmol/L (P=0.004) and serum homocysteine concentrations fell by 1.1 micromol/L and by 0.3 micromol/L, respectively (P<0.05).

CONCLUSIONS:

Finnish pregnant women have low dietary folate intake. Fortified mineral water improved folate status and reduced plasma homocysteine concentrations in the pregnant subjects.

PMID:
17302515
DOI:
10.1515/JPM.2007.024
[Indexed for MEDLINE]
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