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Hepatol Res. 2007 Feb;37(2):101-3.

Distribution frequency of hepatitis C virus genotypes in 2231 patients in Iran.

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Iran University of Medicine, Tehran, Iran.



Given the importance of frequency distribution of HCV genotypes, we studied genotypic distribution of HCV in Iran. In this cross-sectional study, 2231 patients with hepatitis C who presented in hepatitis clinics in Tehran were investigated for HCV genotypes.


Genotyping was performed by genotype specific primers.


The highest frequency was for genotype 1a, with 886 (39.7%) of subjects. Genotype 3a and 1b were the other frequent genotypes, with 613 (27.5%) and 271 (12.1%) subjects, respectively. Of the samples, 401 (18%) had an undetermined genotype. Mixed genotypes were also found in 33 samples (1.6%). Genotype 1b frequency in patients under 20 years old was 10.2%, while its frequency in patients over 60 years old was 18.5%. Genotype 1b frequency significantly increased by age (P = 0.02).


This study indicates that the dominant HCV genotype among patients living in Tehran was 1a.

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