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Br J Dermatol. 2007 Mar;156(3):548-52.

A pilot study of the safety and efficacy of picolinic acid gel in the treatment of acne vulgaris.

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1
Division of Dermatology, Washington University School of Medicine, St Louis, MO, USA. michael.heffernan@wright.edu

Abstract

BACKGROUND:

Cost limitations, adverse effects or lack of efficacy limit the use of current topical therapies in mild to moderate acne vulgaris.

OBJECTIVES:

To determine the safety and efficacy of picolinic acid, a novel zinc finger therapy, in the treatment of mild to moderate acne vulgaris.

METHODS:

Twenty subjects with mild to moderate acne vulgaris were treated at our centre during an open-label study with 10% picolinic acid gel (PCL-016) twice daily to the face over 12 weeks.

RESULTS:

Fifteen patients completed the 12-week open-label study. A reduction of 58.2% (P < 0.001) in mean total lesion count, 55.5% (P < 0.001) in mean inflammatory lesion count and 59.7% (P < 0.005) in noninflammatory lesion count was seen in this population. No serious adverse events or clinically significant changes in laboratory values were noted.

CONCLUSIONS:

Results from this study suggest that 10% picolinic acid gel applied twice daily may be safe and effective in the treatment of mild to moderate acne vulgaris.

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