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Chem Commun (Camb). 2007 Jan 21;(3):301-3. Epub 2006 Oct 27.

A convenient new procedure for converting primary amides into nitriles.

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1
Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 350, Taiwan, R.O.C.

Abstract

An operationally simple and high-yielding procedure has been developed for the conversion of primary amides to the corresponding nitriles, using ethyl dichlorophosphate/DBU as the mild dehydrating agent.

PMID:
17299646
DOI:
10.1039/b614061k
[Indexed for MEDLINE]
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