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Nat Rev Neurosci. 2007 Mar;8(3):206-20. Epub 2007 Feb 14.

Cell adhesion molecules: signalling functions at the synapse.

Author information

1
University of Pennsylvania Medical Center, Department of Neuroscience, BRB II/III, Room 1114, 421 Curie Blvd., Philadelphia, Pennsylvania 19104, USA. dalva@mail.med.upenn.edu

Abstract

Many cell adhesion molecules are localized at synaptic sites in neuronal axons and dendrites. These molecules bridge pre- and postsynaptic specializations but do far more than simply provide a mechanical link between cells. In this review, we will discuss the roles these proteins have during development and at mature synapses. Synaptic adhesion proteins participate in the formation, maturation, function and plasticity of synaptic connections. Together with conventional synaptic transmission mechanisms, these molecules are an important element in the trans-cellular communication mediated by synapses.

PMID:
17299456
PMCID:
PMC4756920
DOI:
10.1038/nrn2075
[Indexed for MEDLINE]
Free PMC Article
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