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Respirology. 2007 Mar;12(2):202-6.

NRAMP1 and TNF-alpha polymorphisms and susceptibility to tuberculosis in Thais.

Author information

1
Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. sisve@mahidol.ac.th

Abstract

OBJECTIVE AND BACKGROUND:

Polymorphisms in the natural resistance-associated macrophage protein gene 1 (NRAMP1) and tumour necrosis factor (TNF)-alpha gene have been found to be associated with susceptibility to tuberculosis in different populations. However, the results are inconsistent. This study aimed to determine whether NRAMP1 and TNF-alpha variants are associated with tuberculosis in Thais.

METHODS:

Polymorphisms of NRAMP1 at INT4, D543N and the 3' untranslated region, and of TNF-alpha at +488, -238, and -308, were examined in 149 tuberculosis patients and 147 healthy controls. PCR using sequence-specific oligonucleotides and sequence-specific priming were used to genotype the NRAMP1 and TNF polymorphisms, respectively.

RESULTS:

There were no significant differences in the distribution of the genotype frequencies for the NRAMP1 and TNF-alpha polymorphisms between the patients and controls.

CONCLUSIONS:

The NRAMP1 and TNF-alpha genes are not associated with susceptibility to tuberculosis in Thais.

[Indexed for MEDLINE]

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