Format

Send to

Choose Destination
Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):232-5.

Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice.

Author information

1
Division of Immunology, Osaka University, Japan.

Abstract

The mechanisms through which pristane or mineral oil can induce plasmacytomas in BALB/c or NZB mice are not fully understood, but involvement of interleukin 6 (IL-6), a growth factor for plasmacytomas and myelomas, has been strongly suggested. To clarify the role of IL-6 in plasmacytomagenesis, a human IL-6 cDNA was introduced into mouse germ lines under the transcriptional control of the murine major histocompatibility complex class I (H-2Ld) promoter. IL-6 transgenic mice of C57BL/6 origin developed a massive plasmacytosis but not plasmacytomas. However, introduction of BALB/c genetic background into IL-6 transgenic mice could generate monoclonal transplantable plasmacytomas with the chromosomal translocation t(12;15). These results provide firm evidence of the critical role of IL-6 in the plasmacytoma development.

PMID:
1729694
PMCID:
PMC48210
DOI:
10.1073/pnas.89.1.232
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center