Levinthal's paradox

Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):20-2. doi: 10.1073/pnas.89.1.20.

Abstract

Levinthal's paradox is that finding the native folded state of a protein by a random search among all possible configurations can take an enormously long time. Yet proteins can fold in seconds or less. Mathematical analysis of a simple model shows that a small and physically reasonable energy bias against locally unfavorable configurations, of the order of a few kT, can reduce Levinthal's time to a biologically significant size.

MeSH terms

  • Mathematics
  • Models, Theoretical
  • Protein Conformation*
  • Proteins / chemistry*

Substances

  • Proteins