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Chin J Physiol. 2006 Oct 31;49(5):258-65.

Effects of cervical-lymphatic blockade on brain edema and infarction volume in cerebral ischemic rats.

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Institute of Physiology, School of Medicine, Shandong University, Jinan 250012, Shandong, P.R.China.

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  • Chin J Physiol. 2006 Dec 31;49(6):342.


To observe the effects of cervical-lymphatic blockade (CLB) on brain edema and infarction volume of ischemic (MCAO) rat, we examined changes in cerebral water content, Ca2+ and glutamate concentrations, cerebral infarction volume and mRNA expression levels of N-methyl-D-aspartame receptor 1 (NMDA receptor 1) in the ischemic (left) hemisphere. The present results demonstrated that all the above indices in rats with middle cerebral artery occlusion plus cervical lymphatic blockade (MCAO+CLB) were markedly higher than those with only middle cerebral artery occlusion (MCAO) at different time points. These results indicated [corrected] that CLB can aggravate cerebral ischemia by increasing brain edema and infarction volume.

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