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Pediatr Nephrol. 2007 May;22(5):747-9. Epub 2007 Feb 10.

Meningococcal disease associated with an acute post-streptococcal complement deficiency.

Author information

1
Bristol Royal Hospital for Children, Bristol, UK.

Abstract

Chronic deficiencies in the complement pathway proteins are associated with an increased risk of meningococcal disease. Such deficiencies are caused by primary congenital immunodeficiency of a complement protein, properdin or mannose binding lectin, or are secondary to consumption of complement by systemic lupus erythematosus (SLE) or membranoproliferative glomerulonephritis (MPGN). Whatever the cause, the complement deficiency is always chronic. Here we report a case of meningococcal disease (MCD) in a child with a transient complement deficiency (CD), caused by post-streptococcal glomerulonephritis (PSGN).

PMID:
17294226
DOI:
10.1007/s00467-006-0394-x
[Indexed for MEDLINE]

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