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Apoptosis. 2007 May;12(5):951-68.

IP3 receptors in cell survival and apoptosis: Ca2+ release and beyond.

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Department of Pathology & Cell Biology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA.


Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) serve to discharge Ca(2+) from ER stores in response to agonist stimulation. The present review summarizes the role of these receptors in models of Ca(2+)-dependent apoptosis. In particular we focus on the regulation of IP(3)Rs by caspase-3 cleavage, cytochrome c, anti-apoptotic proteins and Akt kinase. We also address the evidence that some of the effects of IP(3)Rs in apoptosis may be independent of their ion-channel function. The role of IP(3)Rs in delivering Ca(2+) to the mitochondria is discussed from the perspective of the factors determining inter-organellar dynamics and the spatial proximity of mitochondria and ER membranes.

[Indexed for MEDLINE]

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