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Bioorg Med Chem. 2007 Apr 1;15(7):2631-50. Epub 2007 Jan 26.

Design and synthesis of new potent dipeptidyl peptidase IV inhibitors with enhanced ex vivo duration.

Author information

1
Minase Research Institute, Ono Pharmaceutical Co. Ltd., 3-1-1 Sakurai, Shimamoto, Mishima, Osaka 618-8585, Japan. t.kondou@ono.co.jp

Abstract

A series of 5beta-methylprolyl-2-cyanopyrrolidine analogs were synthesized and evaluated as DPP-IV inhibitors, and the duration of their ex vivo activity was assessed. Comparison of their potency and duration of action was done among three different species. The mode of binding was investigated, and the effect on the plasma glucose level was evaluated. Structure-activity relationships are also presented.

PMID:
17293118
DOI:
10.1016/j.bmc.2007.01.041
[Indexed for MEDLINE]

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