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J Bacteriol. 1992 Jan;174(2):619-22.

Bacteriophage T7 RNA polymerase travels far ahead of ribosomes in vivo.

Author information

1
Laboratoire de Génétique Moléculaire (Centre National de la Recherche Scientifique D1302), Ecole Normale Supérieure, Paris, France.

Abstract

We show that in Escherichia coli at 32 degrees C, the T7 RNA polymerase travels over the lacZ gene about eightfold faster than ribosomes travel over the corresponding mRNA. We discuss how the T7 phage might exploit this high rate in its growth optimization strategy and how it obviates the possible drawbacks of uncoupling transcription from translation.

PMID:
1729251
PMCID:
PMC205757
[Indexed for MEDLINE]
Free PMC Article
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