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Clin Biochem. 2007 Mar;40(5-6):326-9. Epub 2007 Jan 5.

Elevated C-reactive protein in acute coronary syndrome presentation is an independent predictor of long-term mortality and heart failure.

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1
Department of Pathology and Molecular Medicine, McMaster University, 1200 Main St. W., HSC 2N52, Hamilton, ON, Canada L8N 3Z5. kavsakp@mcmaster.ca

Abstract

OBJECTIVES:

To assess the ability of C-reactive protein (CRP) to predict long-term outcomes in a chest pain population.

DESIGN AND METHODS:

CRP was measured at presentation in 446 emergency department patients with acute coronary syndromes. All-cause mortality and hospital discharges for acute myocardial infarction (AMI) and congestive heart failure (CHF) were obtained for up to 8 years following the event.

RESULTS:

Kaplan-Meier analyses indicated that patients with CRP concentrations above the American Heart Association scientific statement cut-off had a higher rate for death and CHF admissions. After adjusting for troponin concentrations, in a Cox proportional hazard model, only CRP concentrations indicative of an acute phase response (i.e., >7.44 mg/L) were associated with a significant risk for death after 5 years and CHF readmission after 2 years.

CONCLUSIONS:

Patients presenting early with chest pain with elevated CRP concentrations have a greater long-term risk for death and heart failure.

[Indexed for MEDLINE]

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