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Med Mal Infect. 1996 Apr;26 Suppl 3:379-85.

[Contribution of molecular biology to typing: Methodological over view.].

[Article in French]

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Unité des Entérobactéries, Unité INSERM 389, Institut Pasteur, 75724 Paris Cedex 15, France.


Molecular biology yielded universal typing methods. However, different methods have different applications. Multilocus enzyme electrophoresis allows precise population genetics studies. Random amplification is useful for quickly comparing a few strains. Pulse field gel electrophoresis, which is more discriminating than ribotyping, is indicated for the study of epidemics which do not last more than a few months. Ribotyping, which gives most stable types, is indicated for tracing clones world-wide and for many years. Automatization of key experimental steps and computer-aided interpretation are essential for an objective comparison of many strains. Databases of molecular typing patterns are in completion.

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